Biochemistry Questions / Evaluate the role of Ndh and Cyd in the bacterial electron transport chain during aerobic respiration. Why are these complexes essential for pathogenesis, and how could they be targeted for antimicrobial drug development?

Targeting Ndh and Cyd for antimicrobial drugs may have potential, as these proteins are only found in bacterial electron transport chains (allowing for selective toxicity). Inhibiting the function of these electron transport complexes may be harder to develop mutation against, due to the essential function of these proteins in aerobic respiration.