Biochemistry Questions Biochemistry Questions / Discuss the process of affinity maturation in antibody production, explaining how B cells increase the affinity of antibodies for antigens. How does affinity maturation contribute to the effectiveness of the immune response? Provide examples to support your explanation.

Affinity maturation is an important process used in the development of B cells, allowing antibody with greater specificity for its target to be synthesised. Through somatic recombination and hypermutation, changes in the variable region occur, allowing natural selection pressures to favour the more specific antibody.

Through affinity maturation, a stronger and more specific adaptive immune response can be formed against a specific antigen.