Biochemistry Questions / Compare and contrast the first generation and second generation antipsychotic drugs.

First generation antipsychotic drugs were found by accident, and were unselective in their action. This meant they had many side effects, including giving the impressing a patient has Parkinson’s. Due to their poor affinity for the target receptor, a high concentration of the drug is needed before any improvement is visible.

Second generation drugs are more selective, but still cause unpleasant side effects.